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Nelson claims that relative to marijuana, products and solutions that contains synthetic cannabinoids “are genuinely very distinctive, and the effects are way more unpredictable

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PB-22 and 5F-PB-22 were the 1st synthetic cannabinoids to include a quinoline substructure and an ester linkage. These compounds are assumed to have check here been synthesized Along with the intention of making a synthetic cannabinoid prodrug, which could enhance absorption and confound detection. Ester bonds are quickly biodegradable by means of spontaneous or endogenous, nonspecific esterase hydrolysis, that has been typically Employed in medicinal chemistry to make ester prodrugs.

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